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Cholesterol Pills – What You Haven’t Heard

You know cholesterol pills will lower your cholesterol. But do you know cholesterol pills don’t prevent heart attacks by lowering cholesterol? They work by what the pharmaceutical companies call “a pleitropic effect” meaning they have so many effects we can’t understand or predict them all.

Isoprene: A Building Block for Cellular Health

Cholesterol pills called statins lower cholesterol by blocking the enzyme that forms a chemical required for the earliest steps of cholesterol manufacture, the making of isoprene units. If you can’t make isoprene units, you can’t make cholesterol. But your body uses isoprene units for a whole bunch of purposes, so taking them out of the cellular stockpile means that you can’t make a whole lot of other things either. Some people’s muscles can’t make the antioxidants their cells use to help manufacture ATP energy, so they feel weak and their hearts (an organ made of muscle!!) get flabby. Some people’s immune systems can’t distinguish healthy cells from malignant mutants or invasive bacteria, and so they develop cancer or infections. Those isoprene units are also important for brain cell growth and memory, so some people taking these pills act as if they’re getting Alzheimer’s. Because every cell in your body needs to make isoprene units, it seems logical that, if you take cholesterol pills long enough or in high enough doses, it’s only a matter of time before they damage your health.

In spite of these risks, I still advise some people to take cholesterol pills. Why? Because some people’s risk of heart attacks is so high and immediate, it’s worth the relatively lower, delayed risk of developing the other medical problems. Male smokers who have had heart attacks and continue to smoke are ideal candidates for statin therapy.

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megyn kelly

This has been life changing

"Let me tell you this has been life-changing. I have all of her books, in audible and ebooks! I have gotten rid of all the hateful 8 oils. I have trained my body to eat its own previously toxic body fat. Download that pod it's a game changer!"

Megyn Kelly
Jesse Watters

Life changing

Deep Nutrition changed my life.

Jesse Watters
Fox News Primetime host

Saved my life

I would like to thank you for literally saving my life. Back in February, I had to be hospitalized while on vacation in Phoenix with an A1C of 11% and had to start taking 2 types of insulin and 2 other meds. I read the Fatburn Fix in April, and followed the program to a tee, and I’m down by 15 pounds, 6.8 A1C, and only one once weekly diabetes medicine. Prior to reading the book, it was almost impossible for me to lose weight as a diabetic. 

Leontyne Tompkins

I feel free

For the last month, I have really been reading all labels on everything. I have completely remove those 8 oils you talk about. I must tell you, I feel great! I have more energy and I am now 197 lbs (have always been around 205 to 210lbs). I eat potatoes with real butter, grass fed steak, pasta with the right toppings. I eat everything! I seem to crave less sugar. I love it! 

Robert Kirkendall

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I had terrible aches and pains everywhere in my body, my hands, shoulders and knees. I feel so much better and the way I feel is motivating me every day! Thank you

Mike Deb Wootan Burcin

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Erica Turrell

Heart Palpitations have Stopped

I’ve lost 20+ pounds (also fasting 16-24 hours daily) and haven’t had palpitations except for one occasion — I had a mini bag of Fritos for the first time in July. And, I feel better now on a daily basis than I ever did all through college.

Mike Wright
Deep Nutrition and Fatburn Fix reader
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I’ve lost over 50 pounds

I’ve lost over 50 pounds. I’m 56 years old. Cutting processed food and unhealthy fats from my diet was one of the first things I did on my health recovery journey...I went cold turkey off the bad oils. Emptied my pantry into the trash and just started eating real food

Mitzi Wilkinson Champion

Knowledge I didn’t know I needed

Your Fatburn Fix book is amazing, my friend. Thank you! I’m an Functional Nutritional Therapy Practitioner and I know my stuff. This is the extra layer of knowledge I didn’t know I needed. Well done!

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Fatburn Fix reader

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I have lost a solid 20 lbs and my bloodwork (after 3 months of eating your way) was even better! I was metabolically healthy (per your book) before I read your book, but barely. Lowering my weight, sealed the deal! I have been talking about you and your book to anyone who will listen...Thank you for all you’ve done and what you continue to do! You are changing lives for the better!

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FatBurn Fix reader

Lost 20 lbs I could never shed

I love your Fatburn Fix!  Has helped me so so much!  I have had the dreaded weight all my life - 20 or so pounds I could never shed.  I have lost that now. I only eat 2 meals a day lunch and dinner with a glass of milk or cappuccino around 4 to hold me over. No snacking and not bad oils.  It has been the key to unlocking my fatburn.  I work out in the am and believe I am burning fat for energy not from food!

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I feel great

My waist is four inches smaller. I feel great and many of the minor aches and pains that I had (knees and lower back) are gone. Also, my muscle tone is amazing, even though I have not increased my workout routine.

Richard Janelle
Completed Dr Cate's online course
Kent Matthes

The go-to for strength and conditioning coaches

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Major League Baseball Agent with WME Sports
Ken D Berry

Dismantles the lie

Dr. Cate dismantles the lie that seed oils are healthy, which may the biggest lie about nutrition and health because it’s so insidious.  

Ken D Berry, MD
Author of Lies My Doctor Told Me
Dr. Drew Pinsky

She knows the chemistry

Dr. Cate alerts us to the harms of seed oils and she’s convincing because she knows the chemistry better than anyone.

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Globally recognized internal medicine and addiction medicine specialist, media personality, LoveLine Host, and New York Times bestselling author
Kelly Starrett

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Dr. Kelly Starrett
Physiotherapist coach and New York Times and Wall Street Journal bestselling author
Brian Lenkzes

Highly recommend The Fatburn Fix

Dr. Shanahan has had a significant impact on my practice of medicine. I am known as a Low Carb Doctor, but I never really appreciated the negative effects of processed seed oils on the health of my patients. I highly recommend The Fatburn Fix to my patients and have a loaner copy in my waiting room. It is amazing how quickly blood sugars and overall health improves with cutting seed oils. It is not just about the carbs!

Dr. Brian Lenkzes, MD
CEO of LowCarbMD San Diego, co-host of Low Carb MD Podcast and host of Life's Best Medicine Podcast
Chris Kaman

Respected in the sports world

Dr. Cate reordered my diet when I was with the L.A. Lakers, and the benefits, for me personally, were felt immediately and have served me to this day. I’ve come to take real food so seriously I started a small family farm. I know of no M.D./nutritionist more respected in the sports world than Dr. Cate Shanahan.

Chris Kaman
NBA Player
Mark Sisson

Brought seed oil issue front and center

Cate brought the seed oil issue front and center. Healthy fats matter. So much so that I created an entire product line to swap out bad fats with good.

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Founding Father of the Primal/Paleo Movement
Dallas Hartwig

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Dallas Hartwig
Attribution author of The Whole 30
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Paul Grewal

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Dr Grewal Internal Medicine, MD, author of Genius Foods
Joesph Mercola

Radically improve your health…

Dr. Shanahan has provided a solid reference that deserves a place in the library of anyone who is seriously interested in nutrition. Her perspective on the vital role that healthy fat has in our diet is novel and, if implemented, can radically improve your health.

Dr. Joseph Mercola
Author of Fat for Fuel and Founder of Mercola.com
Dave Aspery

Pull up a chair…

I have based my work on the idea that getting the right kinds of healthy fats into your body and avoiding the worst fats is essential to optimal health. I've interviewed dozens of the world's top experts about this, and I know of no one who speaks more eloquently on this topic than Dr Cate. If she’s talking fats, pull up a chair. Take notes.

Dave Asprey
Author of the Bulletproof Diet

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I love your Fatburn Fix!  Has helped me so so much!  I have had the dreaded weight all my life - 20 or so pounds I could never shed.  I have lost that now. I only eat 2 meals a day lunch and dinner with a glass of milk or cappuccino around 4 to hold me over. No snacking and not bad oils.  It has been the key to unlocking my fatburn.  

Lauren Smith

Saved my life

I would like to thank you for literally saving my life. Back in February, I had to be hospitalized while on vacation in Phoenix with an A1C of 11% and had to start taking 2 types of insulin and 2 other meds. I read the Fatburn Fix in April, and followed the program to a tee, and I’m down by 15 pounds, 6.8 A1C, and only one once weekly diabetes medicine. 

Leontyne Tompkins

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 I'm crying tears of joy and appreciation for all you've done for me and my health! Without Deep Nutrition and Fatburn Fix, I would literally still be in the vicious cycle I'd been fighting all my life! In a nutshell - I am no longer a compulsive overeating addict suffering under the crushing 'thumb' of all food and alcohol.     

Penni Wicks

 

So if not by lowering cholesterol, how do the Statins work?

Cholesterol pills of the statin variety may prevent heart attacks in some people because of their effects on the immune system. By suppressing the immune system (which needs isoprene units for all kinds of functions) drugs like Lipitor, Vytorin, Pravachol and others have a mild anti-inflammatory effect. Aspirin is another example of an anti-inflammatory medicine. But aspirin’s effect is more focused on the inflammation than it is on fundamental immune system function, and so it’s ability to prevent heart attacks may be as much as 100 times more powerful. And taking aspirin does not increase your risk of developing diabetes. Taking a statin does.

For more information about cholesterol lowering pills, and related information that you aren’t likely to get from your doctor, check these links: (and click your browser’s back button if you want to navigate back here)

For those of you who want to know more about why cholesterol pills make people feel bad, here’s a slightly more technical section: The Nitty Gritty

Dr. Cate

With over two decades of clinical experience and expertise in genetic and biochemical research, Dr. Cate can help you to reverse metabolic disease and reshape your body.

This Post Has 6 Comments

  1. A friend of mine has a very bad leg, very painfull and stone cold all the time. she has just come back from America, where it was 85 degrees and her leg was still stone cold. she has now gone to the doc, and he has prescribed colesterol tablets, she can,t understand this. what can she do. thankyou.

  2. Richard:
    Not at all! If you can change your diet, in a matter of months you can get off those pills. Every one of my TRIM patients who completes the 10 week program can decrease the dose, and as they continue, most can get off the pills within the year.

  3. I’ve heard that once you start taking a cholesterol pill, it’s a life sentence.
    I’ve been taking one for close to three years now. If I eat right, am I still stuck
    taking them for life?

  4. Good on you Josephine,

    I think you are right, and it is important for you to share your insight and experience and keep on doing so. My Dad 87, commenced Lipitor 20mg after an infarct last year. Eight weeks in, (I waited for it) he was getting muscle pain, weakness and general fatigue, he developed memory/cognitive problems. Eventually after several trips back and forth to a great GP; he agreed risk-verses benefit issues, and took Dad off statins. He was also aware of the growing contrary evidence about statins, even though the medical model is still to always prescribe statins.

    As a RN who worked in cardiology 6 years, we would often talk among ourselves, and to our ‘inquiring’ patients – the most commonly asked question? “Why did I have a heart attack if I have low colesterol?” Even then we understood ‘the science’ does not add up. Our nurse educator was prescribed satins, but would not take them for fear of side effects – a very educating point of view that demanded more questions – (Not everyone experiences such severe side effects immediately)

    The pharmaceutical industry has a lot to answer for, and although the medical machine grinds its way forward, people are asking more questions, and sometimes they find answers and research on the net and share their insights.

    Change does happen and will take place, I believe more and more health practitioners are becoming aware of certain discrepancies in their discipline, but not everyone is courageous enough or able to front the issues as Cate is doing. Thank you Dr Cate.

  5. Josephine! Do not despair, your diligence may have saved your mother’s life and certainly your ongoing loving care is priceless to her. What’s more, massage and physical therapy, and good diet, may yet restore your mother’s ability to walk. You are somebody and you can continue to make a difference and spread the word by sharing (as easy as copy and pasting) the story in your comment on this web site into other web sites wherever you think people reading might benefit from learning about your mother’s horrible experience.

  6. “”if you take cholesterol pills long enough or in high enough doses, it’s only a matter of time before they damage your health.””

    Mahalo for that very profound statement. They say that if you commit the sin of having a heart attack or stroke, watch out because your doctor will come at you with a vengeance and scare you into taking a statin drug for the rest of your life. My mother was prescribed 20 mgs of Lipitor after her stroke in 2006. Her doctor told us that Mom had to take it even though she did not have a high cholesterol problem and that if we stopped the drug, the doctor would stop being Mom’s doctor. So since all of the doctor’s in Hilo were not taking new patients, my brother obeyed the doctor so that Mom would be able to have a doctor. Six weeks after starting Lipitor, Mom began repeating questions as her brain began experiencing short term memory loss. About 3 months after being on Lipitor, the cardiologist announced to us that Mom was now pre diabetic and having symptoms of congestive heart failure. Within two years and 9 months, MOM went from being an ambulatory person to someone who could barely walk and who must have a wheel chair or a walker to get around. Even though it didn’t show up in her blood tests, Mom’s skeletal muscles have literally wasted away thanks to Lipitor. As soon as Mom came to stay with me in December 2008, I took her off of Lipitor and announced to any doctor that questioned us that statins had destroyed Mom’s quality of life and that she would not be taking the drug ever again. The 1% to 2% absolute risk reduction is not worth it. After reading about the Allhat study, I feel betrayed by the medical establishment. I have had friends and relatives die of congestive heart failure in the last few years and I can’t help but ask myself, were they taking cholesterol drugs? Its like David fighting Goliath. The medical establishment has turned into an intimidating drug pushing monster that makes its profit off of the very people that it harms or kills. The only way to make the monster stop is to have thousands more of Dr. Cates rise up and say, “No More.”
    The nobodies like me don’t stand a chance.

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